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ea0029p700 | Diabetes | ICEECE2012

Sustained Exendin-4 secretion through gene therapy targeting salivary glands in Zucker fa/fa rats and high fat diet fed mice.

Dicembrini I. , Di Pasquale G. , Raimondi L. , Pagano C. , Egan J. , Cozzi A. , Cinci L. , Manni E. , Loreto A. , Berretti S. , Morelli A. , Baum B. , Maggi M. , Vettor R. , Chiorini J. , Rotella C. , Mannucci E.

Background: Exendin-4 (Ex-4) is a GLP-1 receptor agonist approved for the treatment of Type 2 Diabetes (T2DM). Aim of this study was to characterize the effects of Ex-4 expressed continuously from salivary glands (SG), following adeno-associated virus-mediated (AAV) gene therapy in two different model of obesity and T2DM. Several trials support an AAV good safety and little toxicity profile. Serotype 5 (AAV5) presented enhanced gene transfer activity in SG and an efficient pro...

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Endocrine Abstracts

Sustained Exendin-4 secretion through gene therapy targeting salivary glands in Zucker fa/fa rats and high fat diet fed mice.

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